abstract：:Recent in vivo studies have established astrocytes as a major target for locus coeruleus activation (Bekar et al., 2008), renewing interest in cell culture studies on noradrenergic effects on astrocytes in primary cultures and calling for additional information about the expression of adrenoceptor subtypes on differen...

journal_title：Neurochemistry international

authors： Hertz L,Lovatt D,Goldman SA,Nedergaard M

更新日期：2010-11-01 00:00:00

abstract：:Rasagiline is a propargylamine and irreversible monoamine oxidase (MAO) B inhibitor used for the treatment of Parkinson's disease (PD). It has demonstrated neuroprotective properties in laboratory studies. Current concepts of PD aetiopathogenesis include the role of alpha-synuclein, protein aggregation, free radical m...

journal_title：Neurochemistry international

authors： Chau KY,Cooper JM,Schapira AH

更新日期：2010-11-01 00:00:00

abstract：:Natriuretic peptides and their receptors are widely expressed in mammalian CNS and increasing evidence implicates them in the regulation of neural development, synaptic transmission and processing of information, and neuroprotection. Although the peptides have been mainly localized in neuronal populations they are als...

journal_title：Neurochemistry international

authors： Prado J,Baltrons MA,Pifarré P,García A

更新日期：2010-11-01 00:00:00

abstract：:Viral infections are implicated in the onset and promotion of autoimmunity in genetically predisposed individuals. In this study, immune response patterns to herpes viruses were compared in aquaporin 4 (AQP4) antibody positive central nervous system (CNS) autoimmunity and multiple sclerosis (MS). Serum samples of pati...

journal_title：Neurochemistry international

authors： Sellner J,Cepok S,Kalluri SR,Nestler A,Kleiter I,Kümpfel T,Linker R,Melms A,Menge T,Tumani H,Paul F,Hemmer B,Berthele A

更新日期：2010-11-01 00:00:00

abstract：:Glycine transporter GlyT1 plays important role in maintaining accurate glycine concentration in local brain microenvironment. Transporting efficiency of GlyT1 is strongly affected by the state of its distal C-terminus, which regulates transporter trafficking and cellular surface density. Using selected range of antibo...

journal_title：Neurochemistry international

authors： Baliova M,Jursky F

更新日期：2010-10-01 00:00:00

abstract：:The rat retinal ganglion cell (RGC) line RGC-5 constitutes a widely used model for studying physiological processes in retinal cells. In this paper we investigated the expression of clock and immediately early genes, and calcium mediated responses to physiological stimuli in differentiated and mitotically active RGC-5...

journal_title：Neurochemistry international

authors： Nieto PS,Acosta-Rodríguez VA,Valdez DJ,Guido ME

更新日期：2010-10-01 00:00:00

abstract：:Mitochondria play a pivotal role in the regulation of energy metabolism and apoptotic pathways. Properties and functions of mitochondria might render subsets of selectively vulnerable neurons intrinsically susceptible to a different extent to cellular stress and degeneration. We have investigated the effect of 3-nitro...

journal_title：Neurochemistry international

authors： Singh S,Misiak M,Beyer C,Arnold S

更新日期：2010-10-01 00:00:00

abstract：:Lipid peroxidation has many deleterious effects on cells, and in the nervous system is considered to be involved in the pathogenesis of neurodegenerative diseases. To suppress lipid peroxidation, cells have various defense systems such as glutathione and thioredoxin, and defects in these defense systems will result in...

journal_title：Neurochemistry international

authors： Nagamine S,Kabuta T,Furuta A,Yamamoto K,Takahashi A,Wada K

更新日期：2010-09-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) are expressed in neural progenitor cells (NPCs) and may play important roles in the neurogenesis during embryonic development and adult brain repair following injuries. In the present study, we investigated the expression of metabotropic glutamate receptor 7 (mGluR7) and the p...

journal_title：Neurochemistry international

authors： Tian Y,Liu Y,Chen X,Kang Q,Zhang J,Shi Q,Zhang H

更新日期：2010-08-01 00:00:00

abstract：:Essential omega-3 polyunsaturated fatty acids (omega3) are crucial to brain development and function, being relevant for behavioral performance. In the present study we examined the influence of dietary omega3 in the development of the glutamatergic system and on behavior parameters in rats. Female rats received isoca...

journal_title：Neurochemistry international

authors： Moreira JD,Knorr L,Ganzella M,Thomazi AP,de Souza CG,de Souza DG,Pitta CF,Mello e Souza T,Wofchuk S,Elisabetsky E,Vinadé L,Perry ML,Souza DO

更新日期：2010-05-01 00:00:00

abstract：:Platelet activating factor (PAF) has been suggested to play a critical role in the pathogenesis of neurological disorders. We assessed the effect of PAF against the toxicity of 1-methyl-4-phenylpyridinium (MPP(+)), a parkinsonian toxin, in relation to apoptotic process. PAF exhibited differential effect against the MP...

journal_title：Neurochemistry international

authors： Ha SW,Lee CS

更新日期：2010-05-01 00:00:00

abstract：:There has arisen considerable interest in the study of dopamine D(2/3) agonist binding sites by positron emission tomography (PET), based on the claim that agonist sites represent a functional subset of the total number of sites labeled by more conventional antagonist ligands. To test the basis of this claim, we used ...

journal_title：Neurochemistry international

authors： Minuzzi L,Cumming P

更新日期：2010-05-01 00:00:00

abstract：:Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regula...

journal_title：Neurochemistry international

authors： Zheng GQ,Li Y,Gu Y,Chen XM,Zhou Y,Zhao SZ,Shen J

更新日期：2010-04-01 00:00:00

abstract：:Neuroinflammation is believed to play an important role in neurological diseases such as Alzheimer's disease (AD). Growing evidence suggests that n-3 PUFA have protective effects by inhibiting inflammatory processes including synthesis of eicosanoids from arachidonic acid. There is also some evidence suggesting that i...

journal_title：Neurochemistry international

authors： Boudrault C,Bazinet RP,Kang JX,Ma DW

更新日期：2010-03-01 00:00:00

abstract：:Recent studies suggest that the behavioral effects of chronic antidepressant treatment are mediated by stimulation of hippocampal neuronal plasticity and neurogenesis. The present study was designed to examine the effects of 3,6'-disinapoyl sucrose (DISS), a bioactive component of Polygala tenuifolia Willd, on the exp...

journal_title：Neurochemistry international

authors： Hu Y,Liao HB,Dai-Hong G,Liu P,Wang YY,Rahman K

更新日期：2010-02-01 00:00:00

abstract：:Oxidative stress (OS) has been related to cocaine's actions and also to numerous nervous system pathologies, including seizures. The purpose of this work was to determine the alterations in glutathione (GSH) content, nitrite/nitrate and MDA levels after cocaine-induced toxicity. Male Swiss mice were injected (i.p.) wi...

journal_title：Neurochemistry international

authors： Macêdo DS,Vasconcelos SM,Andrade-Neto M,Belchior LD,Honório Júnior JE,Gonçalves DO,Fonteles MM,Silva MI,Aguiar LM,Viana GS,de Sousa FC

更新日期：2010-01-01 00:00:00

abstract：:Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or...

journal_title：Neurochemistry international

authors： Nguyen JH

更新日期：2010-01-01 00:00:00

abstract：:Multiple signaling pathways via insulin receptor substrate-1 and -2 play crucial roles in health, diseases, and therapeutics (i.e., longevity, tumorigenesis, and neuroprotection). The 90-kDa heat-shock protein (Hsp90) is an emerging target molecule of therapeutics, Hsp90 inhibitors being promising against various dise...

journal_title：Neurochemistry international

authors： Yoshikawa N,Nemoto T,Satoh S,Maruta T,Yanagita T,Chosa E,Wada A

更新日期：2010-01-01 00:00:00

abstract：:Inflammation which is an indispensable participant in tumor progression is intricately linked with redox modulation. The pro-inflammatory cytokine Tumor Necrosis Factor (TNFalpha) elevates reactive oxygen species (ROS) in glioblastoma multiforme (GBM). As both TNFalpha and oxidative stress independently play role in r...

journal_title：Neurochemistry international

authors： Ghosh S,Tewari R,Dixit D,Sen E

更新日期：2010-01-01 00:00:00

abstract：:The present study has been designed to establish the potential benefits from 1-methylnicotinamide (MNA) treatment on brain disorders associated with type 1 diabetes. All experiments were carried out after 6 weeks of streptozotocin-induced diabetes (60 mg/kg of body weight, i.p.) in male Wistar rats treated for 5 weeks...

journal_title：Neurochemistry international

authors： Kuchmerovska T,Shymanskyy I,Chlopicki S,Klimenko A

更新日期：2010-01-01 00:00:00

abstract：:To elucidate the role of Ca(2+)-activated K(+) (K(Ca)) channels in the presynaptic acetylcholine (ACh) release from splanchnic nerve endings and the postsynaptic catecholamine release from chromaffin cells, we applied microdialysis technique to the left adrenal medulla of anesthetized rats and investigated the effects...

journal_title：Neurochemistry international

authors： Akiyama T,Yamazaki T,Kawada T,Shimizu S,Sugimachi M,Shirai M

更新日期：2010-01-01 00:00:00

abstract：:Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT(2A)) have been related to depression pathology. Specific 5-HT(2A) receptor changes seen in BDNF conditional mutant mice suggest that BDNF regulates the 5-HT(2A) receptor level. Here we show a direct effect of BDNF on 5-HT(2A) receptor pr...

journal_title：Neurochemistry international

authors： Trajkovska V,Santini MA,Marcussen AB,Thomsen MS,Hansen HH,Mikkelsen JD,Arneberg L,Kokaia M,Knudsen GM,Aznar S

更新日期：2009-12-01 00:00:00

abstract：:alpha(2)-Adrenoceptors are involved in various physiological functions, particularly in the cardiovascular system and the central nervous system. Different adrenoceptor subtypes (alpha(2A), alpha(2B) and alpha(2C)) have been recognised and the different subtypes may have role in activation of distinct physiological an...

journal_title：Neurochemistry international

authors： Gyires K,Zádori ZS,Török T,Mátyus P

更新日期：2009-12-01 00:00:00

abstract：:Neural stem cells (NSCs) play a crucial role in the development and maturation of the central nervous system. Recently studies suggest that antipsychotic drugs regulate the activities of NSCs. However, the molecular mechanisms underlying antipsychotic-induced changes of the activity of NSCs, particularly protein expre...

journal_title：Neurochemistry international

authors： Kashem MA,Ummehany R,Ukai W,Hashimoto E,Saito T,Mcgregor IS,Matsumoto I

更新日期：2009-12-01 00:00:00

abstract：:Chronic ingestion of caffeine causes dependence and sleep disturbance in children and adolescents. In rodents, the administration of caffeine may produce behavioral cross-sensitization to some psychostimulants, such as dopaminergic psychoactive drugs. Methylphenidate (MPH; Ritalin) is a psychostimulant used in pediatr...

journal_title：Neurochemistry international

authors： Boeck CR,Marques VB,Valvassori SS,Constantino LC,Rosa DV,Lima FF,Romano-Silva MA,Quevedo J

更新日期：2009-09-01 00:00:00

abstract：:While nerve growth factor (NGF) activates various signaling cascades, the phosphatidylinositol 3-kinase (PI3-K)/Akt pathway plays a pivotal role in controlling the survival of neurons, although this activity declines during the aging process. We investigated the effect of forced moderate-intensity treadmill exercise o...

journal_title：Neurochemistry international

authors： Chae CH,Kim HT

更新日期：2009-09-01 00:00:00

abstract：:Astrocytes can exocytotically release the transmitter glutamate. Increased cytosolic Ca(2+) concentration is necessary and sufficient in this process. The source of Ca(2+) for the Ca(2+)-dependent exocytotic release of glutamate from astrocytes predominately comes from endoplasmic reticulum (ER) stores with contributi...

journal_title：Neurochemistry international

authors： Reyes RC,Parpura V

更新日期：2009-07-01 00:00:00

abstract：:The synthesis of neurotransmitter glutamate in brain is mainly carried out by glutaminase enzymes. This synthesis must be exquisitely regulated because of its harmful potential giving rise to excitotoxic damage. It is noteworthy that two glutaminase isozymes coded by different genes are expressed in the brain of mamma...

journal_title：Neurochemistry international

authors： de la Rosa V,Campos-Sandoval JA,Martín-Rufián M,Cardona C,Matés JM,Segura JA,Alonso FJ,Márquez J

更新日期：2009-07-01 00:00:00

abstract：:Astroglial cells have a variety of roles in the central nervous system (CNS), providing a homeostasis for the proper functioning of neuronal cells. The classical view concerning the supportive role of astroglia towards associated neurons has to be extended. A great number of new evidences suggest that astrocytes inter...

journal_title：Neurochemistry international

authors： Struzyńska L

更新日期：2009-07-01 00:00:00

abstract：:Minocycline is neuroprotective in animal models of a number of acute CNS injuries, neurodegenerative diseases and CNS infection. While anti-inflammatory and anti-apoptotic effects of Minocycline have been characterized, the molecular basis for the neuroprotective effects of Minocycline remains unclear. We report here ...

journal_title：Neurochemistry international

authors： Mishra MK,Ghosh D,Duseja R,Basu A

更新日期：2009-06-01 00:00:00

abstract：:The influence of citalopram on regional 5-hydroxytryptamine (serotonin, 5-HT) synthesis, one of the most important presynaptic parameters of serotonergic neurotransmission, was studied. Sprague-Dawley (SPD) rats were used as the controls, and Flinders Resistant Line (FRL) rats were used as auxiliary controls, to hopef...

journal_title：Neurochemistry international

authors： Kanemaru K,Nishi K,Hasegawa S,Diksic M

更新日期：2009-05-01 00:00:00

abstract：:Ubiquitin (Ub) carboxy terminal hydrolase (UCH)-L1 and UCH-L3 are two of the deubiquitinating enzymes expressed in the brain. Both gad mice, which lack UCH-L1 expression and Uchl3 knockout mice exhibit neurodegeneration, although at distinct areas. These phenotypes indicate the importance of UCH-L1 and UCH-L3 in the r...

journal_title：Neurochemistry international

authors： Setsuie R,Sakurai M,Sakaguchi Y,Wada K

更新日期：2009-05-01 00:00:00

abstract：:The ketogenic diet (KD) is used for the treatment of refractory epilepsy in children, however, the mechanism(s) remains largely unknown. Also, the antiepileptogenic potential in animal models of epilepsy has been poorly addressed. Activation of cannabinoid type-1 receptor (CB(1)-R) upon seizure activity may mediate ne...

journal_title：Neurochemistry international

authors： Hansen SL,Nielsen AH,Knudsen KE,Artmann A,Petersen G,Kristiansen U,Hansen SH,Hansen HS

更新日期：2009-03-01 00:00:00

abstract：:Catalpol has been shown to rescue neurons from kinds of damage in vitro and in vivo in previous reports. However, the effect of catalpol on the nitric oxide (NO) system via MAPKs signaling pathway of mesencephalic neurons largely remains to be verified. The current study examined that whether catalpol modulated NO and...

journal_title：Neurochemistry international

authors： Bi J,Jiang B,Hao S,Zhang A,Dong Y,Jiang T,An L

更新日期：2009-03-01 00:00:00

abstract：:Gastrointestinal peptides and hormones are known to penetrate through the utero-placental barrier and regulate fetal development. In the present study, we tested permeation of maternal brain-derived neurotrophic factor (BDNF) to fetuses, using BDNF-gene deficient mice and exogenous BDNF administration. At embryonic da...

journal_title：Neurochemistry international

authors： Kodomari I,Wada E,Nakamura S,Wada K

更新日期：2009-02-01 00:00:00

abstract：:Increased noradrenaline, induced by rapid eye movement (REM) sleep deprivation, stimulates Na-K ATPase activity in the rat brain. The brain contains neurons as well as glia and both possess Na-K ATPase, however, it was not known if REM sleep deprivation affects the enzyme in both types of cells identically. Rats were ...

journal_title：Neurochemistry international

authors： Baskey G,Singh A,Sharma R,Mallick BN

更新日期：2009-01-01 00:00:00

abstract：:We have previously demonstrated that acute hyperhomocysteinemia induces oxidative stress in rat brain. In the present study, we initially investigated the effect of chronic hyperhomocysteinemia on some parameters of oxidative damage, namely total radical-trapping antioxidant potential and activities of antioxidant enz...

journal_title：Neurochemistry international

authors： Matté C,Mackedanz V,Stefanello FM,Scherer EB,Andreazza AC,Zanotto C,Moro AM,Garcia SC,Gonçalves CA,Erdtmann B,Salvador M,Wyse AT

更新日期：2009-01-01 00:00:00

abstract：:Vinpocetine (ethyl apovincaminate), a synthetic derivative of the Vinca minor alkaloid vincamine, is widely used for the treatment of cerebrovascular-related diseases. One of the proposed mechanisms underlying its action is to protect against the cytotoxic effects of glutamate overexposure. Glutamate excitotoxicity le...

journal_title：Neurochemistry international

authors： Tárnok K,Kiss E,Luiten PG,Nyakas C,Tihanyi K,Schlett K,Eisel UL

更新日期：2008-12-01 00:00:00

abstract：:We demonstrate the feasibility and usefulness of the histoblot immunostaining of cryosections of whole hemispheres of healthy and Alzheimer diseased (AD) human brains by localizing a neuron-specific marker, the anti-neuronal nuclei (NeuN) antigen. As expected, cortical NeuN-immunopositive regions were generally thinne...

journal_title：Neurochemistry international

authors： Beliczai Z,Varszegi S,Gulyas B,Halldin C,Kasa P,Gulya K

更新日期：2008-12-01 00:00:00

abstract：:Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. It has been recently described that GM1 induces vasodilation. However, the mechanisms underlying GM1-induced vasodilation were not evaluated to date. Therefore, in this study we in...

journal_title：Neurochemistry international

authors： Furian AF,Oliveira MS,Magni DV,Souza MA,Bortoluzzi VT,Bueno LM,Royes LF,Mello CF

更新日期：2008-12-01 00:00:00